Jurgen Klopp’s men were chasing a 4th straight win the Premier League for the first time this season when they travelled to the St Marys this weekend.
Plagued with injuries, Klopp had to start Origi and Sturridge up front with Coutinho and Lallana behind them hoping to get some goals out of them.
Ronald Koeman on the other end needed to end a bad run of recent form and needed all three points from this game to keep their hopes of European football alive for next season.
And it started brightly for the home side as the Saints were lively in the first 10 minutes but either side could not create too many chances until 15 minutes into the game when a piece of genius from Liverpool magician put them ahead.
Coutinho, as he is getting popular for, pulled one out of the bag 30 yards away from goal to beat Forster and continue his scoring streak in recent games. Daniel Sturridge added another at the end of a swift counter attack that saw the visitors go two up inside half an hour at the St Marys.
They did create plenty of chances and were disallowed a goal for offside but the Red of Merseyside could not add to their lead, something they had no idea would come back and haunt them.
Koeman, who had enough of the first half bought in Wanyama and Mane after half time and the game seemed to have changed for once and for all.
Liverpool just could not get a foot in the game as Southampton started to dominate in the final third and it was Martin Skrtel who replaced Dejan Lovren in the second half who gave Mane a chance to open the scoring for the home side.
He bought Pelle down in the box but Simon Mingolet was there to keep the two goal cushion intact with a fine save from the spot. However, the going got tough for the Men in Black on the night as the Saints piled on the chances.
Sadio Mane who missed the penalty finally opened the scoring from a superb shot from an acute angle to give Southampton some hope before Pelle put the Saints on level terms from a sweet strike from the edge of the box.
Martin Skrtel was now where to be seen for this goal and just minutes later gave away the ball cheaply after a horrible clearance from Mignolet. Pelle set Mane on goal once again and the pacey winger made no mistake and made sure that Liverpool payed for their mistakes on the night.
Koeman was all smiles at the end of the game while Jurgen Klopp was left to rue his decisions at half time. Lovren who though picked up a yellow card, bossed the penalty box and the Reds barely missed his services in the second half when the Saints piled on the pressure.
Sadio Mane did extremely well to take away the game from Liverpool and Koeman’s other half time substitute Wanyama did an equally superb job in the middle to keep Liverpool away from danger.
This victory will see Southampton move to 7th place with 47 points on the board just 4 points away from a top 4 spot. Liverpool on the other end are still 7 points away from a Champions League spot and will need to find some consistency if they are to find anything from this season.