Jean du Plessis is a South African cricketer. On 16 September 2016, du Plessis made his Twenty20 debut for South Western Districts against Northern Cape. One month later, he made his List A debut for South Western Districts in the 2016–17 CSA Provincial One-Day Challenge on 16 October 2016. Du Plessis made his first-class debut for South Western Districts on 1 December 2016 in the 2016–17 Sunfoil 3-Day Cup.
In December 2017, he was named in South Africa’s squad for the 2018 Under-19 Cricket World Cup.