Rafael Nadal suffered a shock exit after being two sets up in the third round match against the Italian Fabio Fognini. Fabio Fognini staged a miraculous comeback by winning the last three sets and ended up beating the Spaniard 3-6, 4-6, 6-4, 6-3, 6-4.

This is the first time Nadal has lost a five-setter match in grand slam events after taking the first two sets.

Check out the Twitter reactions to Rafael Nadal’s shocking defeat:

Rafael Nadal has been knocked out of the US Open, beaten 3-6 4-6 6-4 6-3 6-4 by Italy’s Fabio Fognini. #SSNHQ pic.twitter.com/1OSDWMUvbO

— Sky Sports News HQ (@SkySportsNewsHQ) September 5, 2015

Rafa Nadal’s performances in the last 4 Grand Slams have been as strong as Popeye without his supply of spinach or Samson after a haircut…

— Cricketwallah (@cricketwallah) September 5, 2015

Amazing: Fognini was 0-7 on hard courts in 2015 entering this tournament

— Nick Nemeroff (@NNemeroff) September 5, 2015

2015 is the first year since 2004 in which Rafael Nadal has not won a Grand Slam title. And he only reached two QFs. #USOpen

— Ben Rothenberg (@BenRothenberg) September 5, 2015

Both Nadal and the Bryans came into this season having won a major each year in the previous decade. Streaks end in unison.

— Chris Skelton (@ChrisSkelton87) September 5, 2015

Federer vs. Nadal at the U.S. Open is never going to happen, is it?

— DavidLaw (@DavidLawTennis) September 5, 2015

This is the first time #Fognini has made the fourth round at the #usopen pic.twitter.com/qDwimkJYTE

— US Open Tennis (@usopen) September 5, 2015

The last time #Rafa failed to make it out of 3R at the #usopen was 2005 vs. James Blake. #usopen

— US Open Tennis (@usopen) September 5, 2015

That was Nadal’s first loss at the #usopen since the 2011 final against #Djokovic. He won in 2013 and DNP in 2012 or 2014. #usopen

— US Open Tennis (@usopen) September 5, 2015

Watch Nadal getting dejected after a tough loss: