Newcastle United stunned Manchester City the Etihad Stadium by beating the Premier League champions 0-2 away from home.
Liverpool squeezed out a narrow 2-1 win thanks to a last-gasp winner from defender Lovren and a 86th minute equalizer from under-fire striker Mario Balotelli.
Southampton too needed a late winner from Pelle to seal a 3-2 win over at Stoke City while Tottenham Hotspur cruised to a 2-0 win over Brighton and Hove Albion.
Capital One Cup Fourth Round Results:
Shrewsbury 1 – 2 Chelsea
A Mangan (77) D Drogba (48) J Grandison (og 81)
Bournemouth 2 – 1 West Bromwich Albion
E O’Kane (49) C Wilson (86) T Elphick (og 85)
MK Dons 1 – 2 Sheffield United
B Afobe (pen 67) M Higdon (86, 90+3)
Fulham 2 – 5 Derby
M Dembele (27, 45) C Martin (pen 45+2) J Russell (47) S Dawkins (54, 65) J Hendrick (62)
Liverpool 2 – 1 Swansea City
M Balotelli (86) D Lovren (90+5) M Emnes (65)
Manchester City 0 – 2 Newcastle United
R Aarons (6) M Sissoko (75)
Stoke City 2 – 3 Southampton
S N’Zonzi (49) M Diouf (82) G Pelle (6, 88) S Long (30)
Tottenham Hotspur 2 – 0 Brighton and Hove Albion
E Lamela (54) H Kane (74)
Capital One Cup Quarter Final Fixtures:
Tottenham Hotspur vs Newcastle United
Derby County vs Chelsea
Bournemouth vs Liverpool
Sheffield United vs Southampton
The Quarter Final matches will take place in the third week of December.