1.Barcelona 1-2 Real Madrid (La Liga, April 2012):

Probably the most important win for Mourinho with Madrid as the win against Barcelona paved the way for La Liga glory. Cristiano Ronaldo scored the winner as Madrid closed in on its first title in four years. The goal led to the famous “Calma” celebration from the Portuguese forward. The season was the last season in Barcelona dugout for Guardiola as he decided to call time on his career at Barca after losing the league to Real and getting eliminated in the Champions League by Chelsea.